vascularmicrornas.com © 2012

  Leducq-Network for Vascular MicroRNAs (MIRVAD) 

Vascular system assessed by microCT

picture kindly provided by Zhen Zhuang, Yale University

Publications based on work funded by Fondation Leducq, which acknowledge the foundation’s support (published or in press), since the start of Leducq funding in 2014

 

 

2016

Aryal B, Rotllan N, Araldi E, Ramírez CM, He S, Chousterman BG, Fenn AM, Wanschel A, Madrigal-Matute J, Warrier N, Martin-Ventura JL, Swirski FK, Suárez Y, Fernández-Hernando C (2016). Macrophage ANGPTL4 deficiency enhances vascular inflammation and promotes atherogenesis. Nat Commun. 7:12313.

 

Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M (2016). Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation. [Epub ahead of print]

 

Barwari T, Skroblin P, Mayr M (2016). When sweet turns salty: glucose-induced suppression of atrial natriuretic peptide by microRNA-425. J Am Coll Cardiol. 67:813-816.

 

Beermann J, Piccoli MT, Viereck J, Thum T (2016). Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. Physiol Rev. 96:1297-1325.

 

Caporali A, Miscianinov V, Saif J, Emanueli C (2016). MicroRNA transport in cardiovascular complication of diabetes, Biochim Biophys Acta, [Epub ahead of print]

 

Chamorro-Jorganes A, Lee MY, Araldi E, Landskroner-Eiger S, Fernandez-Fuertes M, Sahraei M, Quiles Del Rey M, van Solingen C, Yu J, Fernandez-Hernando C, Sessa WC, Suarez Y (2016). VEGF-Induced Expression of miR-17-92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis. Circ Res. 118, 38-47.

 

Daniel JM, Prock A, Dutzmann J, Sonnenschein K, Thum T, Bauersachs J, Sedding DG (2016). Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation. Arterioscler Thromb Vasc Biol. 36:317-327.

 

Fiedler J, Thum T (2016). New Insights Into miR-17-92 Cluster Regulation and Angiogenesis. Circ Res. 118:9-11.

 

Gomes RS, Skroblin P, Munster AB, Tomlins H, Langley SR, Zampetaki A, Yin X, Wardle FC, Mayr M (2016). "Young at heart": Regenerative potential linked to immature cardiac phenotypes. J Mol Cell Cardiol. 92:105-108.

 

Gupta SK, Thum T (2016). Non-coding RNAs as orchestrators of autophagic processes. J Mol Cell Cardiol. 95:26-30.

 

Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T (2016). MicroRNA-based therapy of Gata2-deficient vascular disease. Circulation, in press

 

Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton AC, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley SR, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey RF, Mayr M (2016). Association of microRNAs and YRNAs with platelet function. Circ Res. 118:420-432.

 

Leistner DM, Boeckel JN, Reis SM, Thome CE, De Rosa R, Keller T, Palapies L, Fichtlscherer S, Dimmeler S, Zeiher AM. (2016) Transcoronary gradients of vascular miRNAs and coronary atherosclerotic plaque characteristics. Eur Heart J. 37:1738-1749.

 

Müller, R, Weirick T, John D, Militello D, Chen W, Dimmeler S, Uchida S (2016). ANGIOGENES: knowledge database for protein-coding and noncoding RNA genes in endothelial cells. Sci Reports, in press

 

de Gonzalo-Calvo D, Kenneweg F, Bang C, Toro R, van der Meer RW, Rijzewijk LJ, Smit JW,Lamb HJ,Llorente-Cortes V, Thum T (2016). Response to pioglitazone therapy in type 2 diabetes mellitus: circulating long non-coding RNAs in personalized medicine. J Am Coll Cardiol, in press.

 

de Gonzalo-Calvo D, Kenneweg F, Bang C, Toro R, van der Meer RW, Rijzewijk LJ, Smit JW,Lamb HJ,Llorente-Cortes V, Thum T (2016). Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes. Sci Rep, in press.

 

Pauta M, Rotllan N, Fernández-Hernando A, Langhi C, Ribera J, Boix L, Bruix J, Jimenez W, Suárez Y, Ford DA, Baldán A, Birnbaum MJ, Morales-Ruiz M, Fernández-Hernando C (2016). Akt-mediated FoxO1 inhibition is required for liver regeneration. Hepatology. 63:1660-74.

 

Piccoli MT, Bär C, Thum T (2016). Non-coding RNAs as modulators of the cardiac fibroblast phenotype. J Mol Cell Cardiol. 92:75-81.

 

Price NL, Holtrup B, Wabitsh M, Rodeheffer M, Bianchini L, Suárez Y, Fernández-Hernando C (2016). SREBP-1c/miR-33b genomic loci controls adipocyte differentiation. Mol Cell Biol. 36:1180-93.

 

Temo B, Joshi A, Mayr M (2016). Topic of the week: microRNAs in cardiovascular disease. J Am Coll Cardiol, in press

 

Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC (2016). Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Mol Med. 8:643-53.

 

Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S, Thum T (2016). Long noncoding RNA Chast promotes cardiac remodeling. Sci Transl Med. 8:326ra22.

 

Weirick T, Militello G, Müller R, John D, Dimmeler S, Uchida S. (2016) The identification and characterization of novel transcripts from RNA-seq data. Brief Bioinform. 17:678-85.

 

Willeit P, Skroblin P, Kiechl S, Fernández-Hernando C, Mayr M (2016). Liver microRNAs: potential mediators and biomarkers for metabolic and cardiovascular disease? Eur Heart J. [Epub ahead of print]

 

Zampetaki A, Willeit P, Burr S, Yin X, Langley SR, Kiechl S, Klein R, Rossing P, Chaturvedi N, Mayr M (2016). Angiogenic microRNAs linked to incidence and progression of diabetic retinopathy in type 1 diabetes. Diabetes. 65:216-27.

 

 

2015

Angelini TG, Emanueli C (2015). MicroRNAs as clinical biomarkers? Frontiers in Genetics. 6:240.

 

Beltrami C, Angelini TG, Emanueli C (2015). Noncoding RNAs in diabetes vascular complications, Journal of Molecular and Cellular Cardiology, 89: 42-50.

 

Boeckel JN, Jaé N, Heumüller AW, Chen W, Boon RA, Stellos K, Zeiher AM, John D, Uchida S, Dimmeler S. (2015) Identification and Characterization of Hypoxia-Regulated Endothelial Circular RNA. Circ Res.117:884-890.

 

Boon RA, Dimmeler S. (2015) MicroRNAs in myocardial infarction. Nat Rev Cardiol. 12:135-142.

 

Caporali A, Meloni M, Nailor A, Mitić T, Shantikumar S, Riu F, Graciela BSN, Lorraine R, Marie B, KatareR, Voellenkle C, Verkade P. Martelli F, Madeddu P, Emanueli C (2015). P75NTR-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte–endothelial crosstalk in diabetes after limb ischaemia. Nature Communications. 6:8024.

 

Caputo M, Saif J, Rajakaruna C, Brooks M, Angelini GD, Emanueli C (2015). MicroRNAs in vascular tissue engineering and post-ischemic neovascularization. Advanced Drug Delivery Reviews. 88:78-91.

 

Chamorro-Jorganes, A., Lee, M.Y., Araldi, E., Landskroner-Eiger, S., Fernandez-Fuertes, M,, Sahraei, M., Quiles Del Rey, M., van Solingen, C., Yu, J., Fernandez-Hernando, C., Sessa, W.C. and Suarez, Y. (2016). VEGF-Induced Expression of miR-17~92 Cluster in Endothelial Cells is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis. Circulation Research 1181 (1):38-47 .

 

Emanueli C, Shearn AIU, Angelini GD, Sahoo S (2015). Exosomes and exosomal miRNAs in cardiovascular protection and repair. Vascular pharmacology. 71:24-30.

 

Fiedler J, Breckwoldt K, Remmele CW, Hartmann D, Dittrich M, Pfanne A, Just A, Xiao K, Kunz M, Müller T, Hansen A, Geffers R, Dandekar T, Eschenhagen T, Thum T (2015). Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization. J Am Coll Cardiol. 66:2005-2015.

 

Floris I, Descamps B, Vardeu A, Mitić T, Posadino AM, Shantikumar S, Sala-Newby G, Capobianco G, Mangialardi G, Howard L, Dessole S, Urrutia R, Pintus G, Emanueli C (2015). Gestational Diabetes Mellitus Impairs Fetal Endothelial Cell Functions Through a Mechanism Involving MicroRNA-101 and Histone Methyltransferase Enhancer of Zester Homolog-2. Arterioscler Thromb Vasc Biol. 35:664-674.

 

Goedeke L, Rotllan N, Ramírez CM, Aranda JF, Canfrán-Duque A, Araldi E, Fernández-Hernando A, de Cabo R, Baldán A, Suárez Y, Fernández-Hernando C (2015). miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic levels in mice. Atherosclerosis. 243:499-509.

 

Goedeke L, Rotllan N, Canfrán-Duque A, Aranda JF, Ramírez CM, Araldi E, Lin CS, Anderson NN, Wagschal A, de Cabo R, Horton JD, Lasuncion MA, Näär AM, Suárez Y, Fernández-Hernando C (2015). MicroRNA-148a regulates LDLR and ABCA1 expression and controls circulating levels of LDL and HDL cholesterol. Nat Med. 21:1280-1289.

 

Kaudewitz D, Zampetaki A, Mayr M (2015). MicroRNA biomarkers for coronary artery disease? Curr Atheroscler Rep. 17:70.

 

Landskroner-Eiger S, Qiu C, Perrotta P, Siragusa M, Lee MY, Ulrich V, Luciano AK, Zhuang ZW,Corti F, Simons M, Montgomery RL, Wu D, Yu J, Sessa WC (2015). Endothelial miR-17~92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling. Proc Natl Acad Sci U S A. 112:12812-12817.

 

Li XG, Roivainen A, Bergman J, Heinonen A, Bengel F, Thum T, Knuuti J (2015). Enabling [(18)F]-bicyclo[6.1.0]nonyne for oligonucleotide conjugation for positron emission tomography applications: [(18)F]-anti-microRNA-21 as an example. Chem Commun (Camb). 51:9821-9824.

 

Rotllan N, Chamorro-Jorganes A, Wanschel AC, Aryal B, Aranda JF, Goedeke L, Salerno AG, Araldi E, Ramírez CM, Sessa WC, Suárez Y, Fernández-Hernando C (2015). Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis. FASEB J. 29:597-610.

 

Smith T, Rajakaruna C, Caputo M, Emanueli C (2015). MicroRNAs in congenital heart disease. Annals of Translational Medicine. 3:333.

 

Viereck J, Kumarswamy R, Thum T (2015). Long Noncoding RNAs as Inducers and Terminators of Vascular Development. Circulation. 131:1236-1238.

 

Thum T, Condorelli G (2015). Long non-coding RNAs and microRNAs in cardiovascular pathophysiology. Circ Res., 116:751-762.

 

Zampetaki A, Mayr M (2015). Sweet dicer: impairment of micro-RNA processing by diabetes. Circ Res. 117:116-8.

 

Wagschal A, Najafi-Shoushtari SN, Wang L, Goedeke L, Sinha S, deLemos AS, Black JC, Ramírez CM, Li Y, Tewhey R, Hatoum I, Shah N, Kristo F, Psychogios N, Vrbanac V, Lu YC, Hla T, de Cabo R, Tsang JS, Schadt E, Sabeti PC, Kathiresan S, Cohen DE, Whetstine J, Chung RT, Fernández-Hernando C, Kaplan LM, Bernards A, Gerszten RE, Näär AM (2015). Genome-Wide Identification of MicroRNAs Regulating Cholesterol/Lipid homeostasis. Nat Med. 21(11):1290-1297.

 

Zwadlo C, Schmidtmann E, Szaroszyk M, Kattih B, Froese N, Hinz H, Schmitto JD, Widder J, Batkai S, Bähre H, Kaever V, Thum T, Bauersachs J, Heineke J (2015). Anti-Androgenic Therapy with Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction. Circulation. 131(12):1071-1081.

 

 

2014

Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T (2014). Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest. 124:2136-2146.

 

Canfrán-Duque A, Ramirez CM, Goedeke L, Lin CS and Fernández-Hernando C (2014). microRNAs and HDL life cycle. Cardiovasc Res. 103:414-422.

 

Goedeke L, Aranda JF, Fernández-Hernando C (2014). microRNA regulation of lipoprotein metabolism. Curr Opin Lipidol. 25:282-288.

 

Goedeke L, Salerno A, Ramírez CM, Guo L, Allen RM, Yin X, Langley SR, Esau C, Wanschel AC, Fisher EA, Suárez Y, Baldán A, Mayr M, Fernández-Hernando C (2014). Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice. EMBO Mol Med. 6:1133-1141.

 

Hirsch E, Nagai R, Thum T (2014). Heterocellular signalling and crosstalk in the heart in ischaemia and heart failure. Cardiovasc Res. 102:191-193.

 

Kane NM, Thrasher AJ, Angelini GD, Emanueli C (2014). Concise review: MicroRNAs as modulators of stem cells and angiogenesis. Stem Cells. 32:1059-1066.

 

Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A, Lemesle G, de Groote P, Pinet F, Thum T (2014). Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure. Circ Res. 114:1569-1575.

 

Kumarswamy R, Volkmann I, Beermann J, Napp LC, Jabs O, Bhayadia R, Melk A, Ucar A, Chowdhury K, Lorenzen JM, Gupta SK, Batkai S, Thum T (2014). Vascular importance of the miR-212/132 cluster. Eur Heart J. 35:3224-3231.

 

Kunz M, Xiao K, Liang C, Viereck J, Pachel C, Frantz S, Thum T, Dandekar T (2014). Bioinformatics of cardiovascular miRNA biology. J Mol Cell Cardiol. 89:3-10.

 

Price NL, Ramirez CM, Fernández-Hernando C (2014). Relevance of microRNA in metabolic diseases.Crit Rev Clin Lab Sci. 51:305-320.

 

Saif J, Emanueli C (2014). miRNAs in post-ischaemic angiogenesis and vascular remodelling. Biochem Soc Trans. 42:1629-1636.

 

Sala F, Aranda JF, Rotllan N, Ramírez CM, Elia L, Condorelli G, Catapano AL, Fernández-Hernando C, Norata DG (2014). miR-143/145 deficiency protects against the progression of atherosclerosis in Ldlr-/- mice. Thromb Haemost. 112:796-802.

 

Skroblin P, Mayr M (2014). "Going long": long non-coding RNAs as biomarkers. Circ Res. 115(7):607-609.

 

Thum T, Kumarswamy R (2014). The smooth long noncoding RNA SENCR. Arterioscler Thromb Vasc Biol. 34:1124-1125.

 

Thum T, Fiedler J (2014). LINCing MALAT1 and angiogenesis. Circ Res. 114:1366-1368.

 

Zampetaki A, Attia R, Mayr U, Gomes RS, Phinikaridou A, Yin X, Langley SR, Willeit P, Lu R, Fanshawe B, Fava M, Barallobre-Barreiro J, Molenaar C, So PW, Abbas A, Jahangiri M, Waltham M, Botnar R, Smith A, Mayr M (2014). Role of miR-195 in aortic aneurysmal disease. Circ Res. 115:857-866.

 

 

 

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